Requests for reprints should be addressed to Paul M. Gordon, PhD, MPH, Laboratory for Physical Activity and Exercise Intervention Research, Department of Physical Medicine and Rehabilitation, University of Michigan, 325 E. Eisenhower, Suite 300, Ann Arbor, MI 4810846202. Clove extract (eugenol) inhibits NFkB-mediated expression of inflammatory cytokines.86,87 Like capsaicin, eugenol inhibits NFkB activation in stimulated macro-phage immune cells,87 reducing their synthesis of COX-2 and inflammatory cytokines.86 Oil of cloves has been used in dental care for centuries, and eugenol is now widely used to promote healing and prevent excessive inflammation after root canal surgery.88,89.
Three groups received drugs daily: the first was only injected with one anti-HIV drug, emtricitabine (FTC); the second group received a daily dose of this drug by mouth in combination with an oral form of another anti-HIV drug called tenofovir; the third was injected with FTC and a high dose of tenofovir every day.
Common link suggested between autism and diabetes: Study implicates hyperinsulinemia in increased incidence of autism (October 19, 2011) – A review of the genetic and biochemical abnormalities associated with autism reveals a possible link between the widely diagnosed neurological disorder and Type 2 diabetes, another medical disorder on the rise in recent decades… > full story.
Researchers conducted a real-time study of thirteen volunteers to determine whether a red wine with a verified high polyphenol content differs from alcohol in its effects on specific markers associated with a greater risk of high blood pressure, coronary artery disease and heart failure.
Basil and rosemary extracts, which contain ursolic acid, reduce cancer cell proliferation and tumor progression through NFkB inhibition.94-96 By inactivating NFkB, ursolic acid prevents initiated cells from reproducing and also triggers tumor cell death.95 This compound further down-regulates molecules that are required for tumor invasion and metastasis.96 Ursolic acid works through its effects on NFkB to induce resting macrophage immune cells, and thus to participate in tumor cell destruction in the early stages of cancer.97 Ursolic acid derivatives that inhibit NFkB have been shown to suppress pro-inflammatory enzyme expression in mouse models of inflammation.98 This effect has been associated with reduced cardiac fibrosis (scar tissue) in the heart tissue of diabetic mice.94.