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Featured Research on Science Daily: New method for researching understudied malaria-spreading mosquitoes. When laboratory rats were fed sufficient alcohol to produce alcoholic fatty liver with liver cell inflammation and necrosis, dietary curcumin inhibited NFkB activation, preventing both the microscopic and biochemical changes associated with alcoholic liver disease.40 In an experimental model of non-alcoholic fatty liver degeneration (which induces substantial oxidative stress), investigators found that dietary curcumin significantly reduced inflammation and the release of inflammatory modulators through NFkB inhibition.41.science daily

Almost overnight, the unloved Jatropha curcushas become an agricultural and economic celebrity, with the discovery that it may be the ideal biofuel crop, an alternative to fossil fuels for a world dangerously dependent on oil supplies and deeply alarmed by the effects of global warming.

Garlic has now been shown to exert its anti-inflammatory and immunomodulatory effects by inhibiting NFkB.37,99 Garlic extracts lowered NFkB activity by up to 41{b2ad4701019a2d48c4572069af24a4bdc560ed22d15daf1c3e71cbb64cb01f7f} in human blood and kidney cells that had been exposed to an inflammation-provoking challenge, thus reducing the expression of certain cytokines.100 These effects may be linked to the observation that a garlic compound inhibits damage to endothelial cells lining blood vessels and reduces atherosclerotic changes.101 Garlic’s inhibition of NFkB leads to reduced production of chemicals that cause lipid peroxidation, and this could provide further protection from atherosclerosis.102 NFkB inhibition is credited for garlic’s ability to protect liver cells from auto-immune damage in an animal model,103 as well as induce cell death in leukemia.104.

Protein that fuels lethal breast cancer growth emerges as potential new drug target (October 19, 2011) – A protein in the nucleus of breast cancer cells that plays a role in fueling the growth of aggressive tumors may be a good target for new drugs, reports a research team… > full story.science dailyscience daily

Sean Carroll is the Alan Wilson Professor of Molecular Biology and Genetics at UW-Madison, and author of the new book, The Serengeti Rules: The Quest to Discover How Life Works and Why It Matters His book uses true stories of scientific discovery to explain how scientists connected the dots and came to understand that all of life is interconnected.